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Palermo is the biggest neighborhood in Buenos Aires, once home to Che Guevara and Argentine writer Jorge Luis Borges. North of Recoleta with Rio de la Plata to the east, it’s made up of several Palermos (Norte, Chico, Alto to name a few). But it’s the transformed Palermo Viejo which attracts locals, expats and visitors to its bars, cafes, and restaurants. You'll find many of these around Plaza Serrano and Plaza Armenia in tree-lined Palermo Soho, where street culture, craft markets, and shops feed into the area’s alternative vibe. Palermo Hollywood is nearby and is similarly abundant in sidewalk cafes, rooftop bars, and parillas/steakhouses. This is where you'll also find clubs such as Club Atlético Palermo.

It’s not short on sights either, with the Museum of Latin American Art, Buenos Aires, or MALBA and National Museum of Decorative Arts. The neighborhood is also home to 400 hectares of lakes and parkland in Bosques de Palermo or Parque Tres de Febrero. Inside, find botanic gardens and the calming oasis of the Jardín Japonés, one of the largest Japanese gardens outside of Japan.

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